Short Course Description
How is protein synthesis regulated in cells?
How do cells deal with stressful situations that affect their protein homeostasis?
How can cells recruit such mechanisms to counter viral infection?
How are these mechanisms usurped by the cancer cell?
Course contents: The course focuses on the molecular mechanisms of the cellular responses to stress. In particular, we study the integrated cell response (ISR), how this response is activated in distinct biological scenarios, and the manners by which it is affected in cancer. We initiate with an introduction to the regulation of translation and the mechanisms of maintenance of proteostasis. This is followed by introducing the cellular mechanisms that deal with proteotoxic stress. Lastly, both phenomena are inserted into contexts of viral infection and cancer-cell transformation.
Grading: 50% of the grade is based on an in-class presentation of a recent study (selected from a list of high-profile papers). The additional 50% is based on a home exam.
Full syllabus is to be published
