Short Course Description
Maintaining the homeostasis in the cell requires integrative reactions involving multiple molecular mechanisms. Success or lack of success in regulating homeostasis can be a decisive factor that differentiates between health and disease. Indeed, responses to stress conditions encompass the entire spectrum of cellular activity, which aims to promote the synthesis/turnover of RNA, proteins (proteostasis) and organelles to enable an adequate response to the changing conditions. The mechanisms involved are the subject of intensive research and serve as targets for new treatments. In this course we will learn the molecular mechanisms involved in the reactions to equilibrium-breaking conditions with an emphasis on various sources of cellular stress, genetic diseases, improper folding of proteins and viral infection. The course will focus on mammalian systems. In addition, we will expand on the experimental techniques involved in the study of responses to stress conditions, and on the model systems currently used to study these issues.
The final score will be determined by: 50% active participation, 50% final exam
Full Syllabus
