Course Number 0421-3816-01
Course Name Introduction to Structural Biology
Academic Unit The George S. Wise Faculty of Life Sciences -
Biochemistry and Molecular Biology
Lecturer Prof. Nir Ben-TalContact
Lecturer Prof. Joel HirschContact
Contact Email:
Office Hours By appointmentBuilding: Sherman Life , Room: 631
Contact Email:
Office Hours By appointmentBuilding: Sherman Life , Room: 621
Mode of Instruction Lecture
Credit Hours 3
Semester 2022/1
Day Sun
Hours 12:00-13:00
Building Porter Life
Room 006
Semester 2022/1
Day Wed
Hours 10:00-12:00
Building Porter Life
Room 006
Course is taught in English
Syllabus Not Found

Short Course Description

Proteins and nucleic acids (DNA and RNA) are highly complex macromolecules that are actively involved in the most basic and important aspects of life. The course will provide the student with description of the high-resolution structure and motion of these macromolecules, and discussion of the relationship between both these aspects and function in health and disease. The aim is to provide the student with the ability to read, understand, and critically assess publications in the field, e.g., the introduction of a new protein structure.

Specific topics
+ Physical forces important in biological macromolecular structure
+ Structural considerations and motifs
+ Methods of structure determination/prediction
+ Thermodynamics and stability
+ Dynamics and folding
+ Membrane proteins
+ Molecular recognition and interactions of proteins with small molecules and with nucleic acids
+ Nucleic acid structure and function

Recommended Textbooks:
1. Kessel and Ben-Tal, Introduction to Proteins: Structure, Function and Motion, 2nd Edition
2. Branden and Tooze, Introduction to Protein Structure, 2nd edition
3. Berg, Biochemistry, 8th edition
4. Lesk, Introduction to Protein Architecture
5. Creighton, Proteins: Structures and Molecular Properties

Full Syllabus
Course Requirements

Take-home exam

Students may be required to submit additional assignments
Full requirements as stated in full syllabus

The specific prerequisites of the course,
according to the study program, appears on the program page of the handbook

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